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Search Results for " isocitrate dehydrogenase (idh) "

15

Compounds

Cat No. Product Name Synonyms Targets
T15551 IDH889 Dehydrogenase
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
T15550 IDH-305 Dehydrogenase
IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (...
T16161 Mutant IDH1 inhibitor Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
TQ0042 BAY-1436032 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1).
T2104 AGI-5198 IDH-C35 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
AGI-5198 (IDH-C35) is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
T7741 DS-1001b Dehydrogenase , Isocitrate Dehydrogenase (IDH)
DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1)
T12128 Mutant IDH1-IN-2 Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor
T1809 AGI-6780 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T2346 Enasidenib AG-221 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Enasidenib (AG-221) is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity.
T16384 Olutasidenib FT-2102 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso...
T2043 Mutant IDH1-IN-1 IDH1-IN-1 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
T3617 Ivosidenib AG-120 Dehydrogenase , Isocitrate Dehydrogenase (IDH)
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhi...
T7307 Vorasidenib PVM/MA,AG-881 Isocitrate Dehydrogenase (IDH)
Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
T12129 Mutant IDH1-IN-4 Others
Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor.
T39716 Mutant IDH1-IN-6 Mutant IDH1-IN-6
Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R...
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